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Intestinal Absorption of D-Glucose, D-Galactose and L-Leucine in Male Growing Rats Fed a Raw Field Bean (Vicia faba L.) Diet^1,2,3,

University of Navarra (Pamplona), Spain⁴ and and Massachusetts Institute of Technology, Cambridge, MA 02139^,5

Abstract

Male growing rats were fed diets containing either raw field bean (Vicia faba L.) or casein as the only source of protein. Diets were fed ad libitum for 5 weeks. Body weight gain was significantly impaired, and rates of both in vivo and in vitro intestinal absorption of D-glucose, D-galactose and L-leucine were reduced, in rats fed the legume diet. The addition of methionine to the bean diet did not alter either growth or intestinal absorption rates. No significant differences in intestinal oxygen uptake were found between the treatment groups. It is suggested that the antinutritive substances contained in the raw legume Vicia faba are responsible for the inhibitory effects observed in this experiment.

¹ Requests for reprints should be addressed to: Dr. S. Santidrian, Dept. of Nutr. and Food Sci., Massachusetts Institute of Technology, Building 56-325, Cambridge, MA 02139.

² The author wishes to express his gratitude to Drs. Larralde and Bello, from the Dept. of Nutr. (University of Navarra, Pamplona, Spain) for their valuable help and suggestions, and to Mr. W. Oliver for his assistance with the Computer System of the Clinical Research Center at the Massachusetts Institute of Technology. The author is also indebted to Mr. P. Coppola, Dept. of Nutr. of the School of Public Health, Harvard Univ., Boston, MA for his assistance in the preparation of the manuscript.

³ The study was carried out in part while the author was on a leave of absence from the Dept. of Nutr., Univ. of Navarra, Pamplona, Spain, for postdoctoral training at MIT.

⁴ Dept. of Physiol. (Sec. of Nutr.).

⁵ Dept. of Nutr. and Food Sci.