J. Anim Sci.
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J. Anim Sci. 1981. 53:80-90.
© 1981 American Society of Animal Science
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Androgen and Glucocorticoid Receptors in Porcine Skeletal Muscle1

M. Snochowski2, K. Lundström3, E. Dahlberg2, H. Petersson3 and L. E. Edqvist4

Karolinska Institutet, Stockholm, Swedenand Swedish University of Agricultural Sciences, Uppsala, Sweden

Abstract

The presence of free androgen and glucocorticoid receptors was demonstrated in the rectus femoris muscle of the pig. No detectable free androgen receptors were observed in intact male pigs. Androgen receptor characteristics in castrates and gilts were related to the growth rate of the lean meat in the ham. The amount of free androgen receptor was less (P<.05) and the androgen was more tightly bound to its receptor (P<.05) in pigs with above-average ham growth. Moreover, a higher DNA content (P<.01) was also found in these pigs, giving a lower (P<.05) protein to DNA ratio. The anabolic action of androgens is likely to be mediated via androgen receptors in skeletal muscle cytosol. The amounts of free glucocorticoid receptors found were influenced by the pH of the cytosolic fraction. The relationships between cytosolic pH and both the amount of glucocorticoid receptor (positive; P<.01) and plasma levels of Cortisol (negative; P<.05) might reflect the stress to which the pigs are exposed at slaughter.

Footnotes

1 This study was supported by grants from the Swedish Medical Research Council (13 x 2819) and the Swedish Council for Forestry and Agricultural Research. The authors are indebted to Miss Barbro Nasman for superb technical assistance.

2 Depts. of Chem. and Med. Nutr., Karolinska Institutet, Fack, S-104 01 Stockholm, Sweden. Dr. Snochowski's present address: Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jablonna, near Warsaw, Poland.

3 Dept. of Anim. Breed and Genet., Faculty of Agriculture, Swedish Univ. of Agricultural Sciences, S-750 07 Uppsala, Sweden.

4 Dept. of Clin. Chem., Faculty of Veterinary Medicine, Swedish Univ. of Agricultural Sciences, S-750 07 Uppsala, Sweden.






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Copyright © 1981 by the American Society of Animal Science.