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Prevention of Lactic Acidosis in Cattle by Lasalocid or Monensin^1,2,3,

Kansas State University, Manhattan 66506

Abstract

Intraruminal administration of lasalocid or monensin (1.3 mg/kg body weight) effectively prevented glucose- or corn-induced lactic acidosis in cattle. Administering the antibiotics for 7 days before experimentally inducing acidosis with corn (27.5 g/kg body weight), effectively prevented acidosis, while 2 days' were sufficient to prevent glucose-induced acidosis (12.5 g/kg body weight). The different responses observed in the two trials probably stemmed from the difference in amounts of carbohydrate used to induce acidosis. Antibiotic-treated cattle had higher rumen pH values and lower L(+) and D(–) lactate concentrations than control cattle that received no antibiotics. Ruminal VFA in control cattle decreased, while total VFA and the molar proportion of propionate increased in antibiotic-treated cattle after grain engorgement. Control cattle exhibited classic signs of acidosis, such as lowered blood pH; increased blood lactate, particularly D(–) isomer; hemoconcentration, and depleted alkali reserve with a pronounced base deficit. Antibiotic-treated cattle exhibited no signs of systemic acidosis

¹ Contribution No. 81-100-j, Ruminant Nutr. Group, Dept. of Anim. Sci. and Ind., Kansas Agr. Exp. Sta.

² Supported in part by a grant from Hoffmann-LaRoche, Inc., Nutley, NJ.

³ The assistance of Lloyd Manthe with the cattle and Gary Skinner and Nancy Hardesty in the laboratory is appreciated.

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