J. Anim Sci.
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J. Anim Sci. 1981. 52:1360-1375.
© 1981 American Society of Animal Science
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Effect of Indomethacin and Prostaglandin F2{alpha} on Parturition in Swine1

B. S. Nara and N. L. First2

University of Wisconsin, Madison 53706,3

Abstract

Twenty-five Yorkshire sows were used to determine whether prostaglandin F2{alpha} (PGF2{alpha}) is a natural luteolytic agent in swine. The sows were given the following treatments: (1) control vehicles of indomethacin and PGF2{alpha}; (2) PGF2{alpha} infused for 10 hr at .5 mg/hr on day 110 of gestation; (3) indomethacin injected IM at 4 mg/kg twice daily from day 109 to day 116; (4) indomethacin + PGF2{alpha} infusion (treatment 2 and 3), and (5) indomethacin (treatment 3) + PGF2a infused continuously from day 110 until the end of parturition. In treatment 5, infusion was begun at a rate of .5 mg/hr for 24 hr, and then increased to 3 mg/hr for 3 hr, 6 mg/hr for 3 hr and 9 mg/hr until the end of parturition. Controls showed a decline in progesterone, a surge to peak levels in relaxin and an increase in PGF2{alpha}-metabolite (PGF2{alpha}-M) on the day before parturition, and mean length of gestation was 114.9 days. Indomethacin prolonged gestation, to 120 days, and delayed prepartum changes in concentrations of progesterone, relaxin and PGF2{alpha}-M. PGF2a caused a premature decline in progesterone, a surge in relaxin, an increase in PGF2{alpha}-M and premature parturition. Termination of PGF2a infusion in sows treated with indomethacin returned PGF2{alpha}-M to baseline levels, delayed and prolonged delivery and caused a high rate of stillbirths. Supplementation of PGF2{alpha} infusion with high doses of PGF2a for sows treated with indomethacin brought PGF2{alpha}-M to peak levels at parturition and resulted in a normal rapid delivery of live piglets. These results show that PGF2{alpha} is a natural luteolytic agent in swine at term, causing a prepartum decline in progesterone and release of relaxin from the corpora lutea, and that high levels of PGF2{alpha} are needed for rapid delivery.

Footnotes

1 Research supported by the College of Agriculture and Life Sciences, Univ. of Wisconsin, Madison 53706; ARS CSRS Grant No. 616-15-152, and Ford Foundation Grant No. 630-O5O5B.

2 The authors express appreciation to Drs. J. W. Lauderdale, K. T. Kirton and U. F. Axen, The Upjohn Company, for providing the prostaglandin F2a, the antiserum for PGF2a-metabolite RIA and the 13,14-dihydro-15-keto PGF2a, and to Dr. O. D. Sherwood, Dept. of Physiol, and Biophys., Univ. of Illinois, for the assay of relaxin.

3 Dept. of Meat and Anim. Sci. Paper No. 745.






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Copyright © 1981 by the American Society of Animal Science.