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Effect of Lasalocid or Monensin on Lactate-Producing or Using Rumen Bacteria^1,2,

Kansas State University, Manhattan 66506

Abstract

Lasalocid or monensin inhibited most of the lactate-producing rumen bacteria (Butyrivibrio fibrisolvens, Eubacterium cellulosolvens, E. ruminantium, Lacbnospira multiparus, Lactobacillus ruminis, L. vitulinus, Ruminococcus albus, R. flavefaciens, Streptococcus boris). Minimum inhibitory concentrations ranged from .38 to 3.0 µg/ml. Among the lactate producers, those that produce succinate as a major end product (Bacteroides, Selenomonas, Succinimonas, Succinivibrio) were not inhibited by lasalocid or monensin. Also, none of the major lactate fermenters (Anaerovibrio, Megaspbaera, Selenomonas) was inhibited by lasalocid or monensin. Veillonella alcalescens was inhibited by 24 µg/ml of lasalocid but was resistant to monensin. Hence, the reported increase in propionate in lasalocid- or monensin- fed cattle may result from selection for succinate producers and lactate fermenters. Lasalocid and monensin appeared to inhibit selectively the production of L(+), but not D(—) lactic acid. The inhibition of major lactate-producing bacteria (Streptococcus and Lactobacillus) suggests that lasalocid or monensin may be used to prevent lactic acidosis in ruminants.

¹ Contribution 80-344-J, Ruminant Nutr. Group, Dept. of Anita. Sci. and Ind., Kansas Agr. Exp. Sta.

² 2 Supported in part by a grant from Hoffmann-La Roche, Nutley, NJ. Assistance of Dr. A. Davidovich is greatly appreciated.

³ for supply of rumen bacterial cultures, the authors thank Dr. M. J. Allison, National Animal Disease Lab., Ames, IA; Dr. M. P. Bryant and Dr. R. Hespell, Univ. of Illinois, Champaign, and Dr. Min Chen, Dept. of Health, State of New York Albany. Also, the laboratory assistance of Arlyn Cohn, Laurie Gregg and Gary Skinner is gratefully acknowledged.

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