J. Anim Sci.
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J. Anim Sci. 1980. 51:380-385.
© 1980 American Society of Animal Science
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Effect of Intraventricular Serotonin on the Plasma Cortisol Response to Restraint Stress in Unanesthetized Sheep1

Martin J. Frey2 and Gary P. Moberg

University of California3, Davis

Abstract

Serotonin infused into a lateral ventricle of unanesthetized sheep reduced the response of the hypothalamic-pituitary-adrenal axis to restraint stress. However, the attenuation of the adrenal response by serotonin was of only limited duration, suggesting that pharmacological manipulation of serotonin would not be effective in altering the adrenal response to stress.

Footnotes

1 Direct correspondence to: Dr.Gary Moberg, Dept. of Anim. Sci., Univ. of California, Davis 95616.

2 Present address: Cardiovascular Research Institute, Univ. of California, San Francisco.

3 Dept. of Anim. Sci.






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Copyright © 1980 by the American Society of Animal Science.