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Effect of Dietary and Injectable Vitamin E and Selenium in Weanling Swine Antigenically Challenged with Sheep Red Blood Cells^{1 ,2,}

The Ohio Agricultural Research and Development Center, Wooster 44691 and and The Ohio State University, Columbus 43210

Abstract

Two experiments were conducted to evaluate the effect of supplemental vitamin E and (or) Se, provided either in the diet or by injection, on humoral antibody production in weanling swine after an antigenic challenge with sheep red blood cells (SRBC). In the first experiment, a 2 x 2 factorial design was used, with pigs fed either 0 or .5 ppm Se and 0 or 220 IU vitamin E/kg diet. The basal diet contained a natural Se and -tocopherol content of .02 ppm and 7 mg/kg, respectively. In a second 2 x 2 factorial trial, 0 or 6 mg Se and 0 or 220 mg -tocopherol were injected intramuscularly into weanling pigs fed the basal diet without supplemental Se or vitamin E. A fifth treatment group was fed a positive control diet containing both nutrients (.5 ppm Se and 220 IU vitamin E/kg). In both experiments, intraperitoneal injections of SRBC (1 x 10⁸) were administered weekly, with hemagglutination titers determined at these intervals. Hemagglutination assays indicated that vitamin E and Se independently enhanced the immune response, particularly during the latter weeks of the experiment. The combination of both nutrients, provided either in the diet or via injection, resulted in a further increase in hemagglutination titers, suggesting an additive response. Pigs receiving either Se or vitamin E had higher serum concentrations of the nutrient provided. Dietary sources of these nutrients resulted in greater serum and tissue levels than did injections.

¹ Approved for publication as Journal Article 102-79 of The Ohio Agri. Res. and Development Center, Wooster.

² Appreciation is expressed to O. J. Reed and S. Lash for their help in the collection of data and to Drs. J. Holman and F. M. Byers for the statistical analysis.

³ Dept. of Anim. Sci., Ohio Agr. Res. and Development Center, Wooster.

⁴ Dept. of Poul. Sci., Ohio Agr. Res. and Development Center, Wooster.

⁵ Present address: Cargill Research Farm, Elk River MN 55330.

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