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Effect of Hormone Injections on Fatty Acid Composition of Lipid in Muscle and Liver Tissues of New Zealand White Rabbits^{1 ,2,}

Colorado State University, Fort Collins 80523

Abstract

Twelve hormones were used in a series of experiments to test the effect of exogenous administration on fatty acid composition of liver and muscle lipids of New Zealand White rabbits. All of the hormones except Synovex and epinephrine significantly altered the amount of one or more fatty acids. Triiodothyronine (T₃) and thyroxine (T₄) had the greatest effects in muscle lipids and adrenocorticotrophic hormone (ACTH) and Dexamethasone (DEX) had the largest effects on liver lipids. Rabbits injected with T₃ and T₄ had more 18 carbon acids and fewer 14 and 16 carbon acids in muscle lipids than the controls. Liver lipids of rabbits treated with ACTH and DEX had increased amounts of 14 and 16 carbon acids and decreased amounts of 18 carbon acids. The data indicated that T₃ and T₄ may stimulate fatty acid chain elongation and ACTH and DEX may inhibit chain elongation.

¹ Approved for publication as Scientific Series Paper No. 2378 of the Colorado State Univ. Exp. Sta.

² Contributed to Regional Project NCR-97.