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Biotin Deficiency Syndrome in Pigs Fed Desiccated Egg White¹

State College of Washington

Abstract

A biotin deficiency was produced in the pig by feeding 30 percent of desiccated egg white in the ration. The deficiency symptoms included alopecia, spasticity of the hind legs, cracks in the feet and a dermatosis of the skin characterized by dryness, roughness and a brownish exudate. This syndrome was prevented by intramuscular injection of 100 micrograms of biotin per pig per day.

A biotin deficiency in the pig resulted in 50 percent more feed being required per pound of gain and a decrease of 45 percent in rate of daily gain.

¹ Published as Scientific Paper No. 655. College of Agriculture and Agricultural Experiment Station, State College, of Washington, Pullman.

² Department of Animal Husbandry. The authors are indebted to Swift & Company, Chicago, Illinois, for supply-ing the desiccated egg white used in this trial, and especially for the cooperation of R. C. Newton, Vice President,and H. S. Mitchell, Chief Chemist. Merck x0026; Company, Rahway, New Jersey, supplied biotin and other B-complex vitamins for this work, and the interest and suggestions of Dr. D. F. Green have been very helpful. Dr. T. H. Jukes,Lederle Laboratories, supplied the mixed tocopherols and menadione. The Bio-Vita 10 MA Natural Shark Liver Oil blend containing 10,000 units of vitamin A per gram was supplied by R. T. Carruthers, Bioproducts, Inc., Astoria, Oregon.

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