J. Anim Sci.
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J. Anim Sci. 1979. 49:1517-1521.
© 1979 American Society of Animal Science
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Serum Glucocorticoids, Growth Hormone and Insulin and Plasma Glucose in Bulls Given Prostaglandin E2 or F2{alpha}1

R. J. Collier2, N. B. Haynes3, T. E. Kiser4 and H. D. Hafs5

Michigan State University, East Lansing 48824

Abstract

Plasma glucose and serum insulin, growth hormone and glucocorticoid concentrations were determined in five yearling bulls given (im) 5, 15 or 30 mg prostaglandin E2(PGE2), 30 mg prostaglandin F2{alpha}(PGF2{alpha}) or saline. Jugular blood was collected at frequent intervals around the time of injection and at .5—hr intervals from 1 to 9 hr after injections. Thirty milligrams PGE2 and 30 mg PGF2{alpha} each caused 15- to 20-fold increases in serum glucocorticoids. Glucocorticoids increased with increasing doses of PGE22. Although PGE2 and PGF2{alpha} each increased blood growth hormone, this effect was about twofold larger after PGE2. By contrast, PGE2 depressed serum insulin about 50% for 1 hr, then insulin increased about sixfold until 3 to 4 hours. Blood serum insulin increased after PGF2{alpha}, but this effect only approached significance (P<.10). Plasma glucose increased about 10 mg/l00ml after PGE2, but was not affected significantly by PGF2{alpha}. Thus, the effects of PGE2 and PGF2{alpha} on hormones which control glucose metabolism differ markedly. We speculate that PGE2 caused a twofold increase in growth hormone secretion within 10 to 20 min, that increased growth hormone induced increased blood glucose within 1 to 2 hr and that increased glucose caused increased insulin secretion at 2 to 4 hr, but we cannot rule out a transitory (1 hr) suppressive effect of PGE2 directly on the pancreas.

Footnotes

1 Michigan Agr. Exp. Sta. Journal Article No. 8929. This research was supported in part by USPHS Research Grant HD 06948. PGF2 a Tromethamine salt and PGE, were kindly provided by Dr. J. W. Lauderdale, The Upjohn Co. The Milk Marketing Board of England provided a travel grant for N. B. H.

2 Present address: Dairy Science Dept., Univ. of Florida, Gainesville 32611.

3 Present address: Dept. of Physiology and Environmental Studies, Univ. of Nottingham School of Agriculture, Sutton Bonington, N. Loughborough, Leicestershire LE12 5RD. England.

4 Present address: Dept. of Animal and Dairy Science, Univ. of Georgia, Athens 30602.

5 Animal Reproduction Laboratory, Dept. of Dairy Science.






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Copyright © 1979 by the American Society of Animal Science.