J. Anim Sci.
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J. Anim Sci. 1979. 49:1270-1275.
© 1979 American Society of Animal Science
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Negative Effect of Bovine Pineal Gland Extract and Positive Effect of Supplemental Lighting on Lactation in Mice1 ,,2

Martin T. Sørensen3 and R. R. Hacker

University of Guelph4, Guelph, Ontario, Canada

Abstract

The effect of bovine pineal extract and light duration on lactation in mice was examined in two experiments. In Exp. I, groups of lactating mice were injected intraperitoneally with 0, .5, 1.0, 2.0 and 4.0 mg extractable protein from a bovine pineal crude extract. The highest dose level was equal to .14 g of pineal tissue. Neither litter (eight pups per litter) weight gains, which were used as a measurement of milk yield, nor dam weight gains were different (P>.10) among treatment groups in a 14-day lactation period.

In Exp. II, groups of lactating mice (14 day lactation period) on two light schedules (16 hr vs 8 hr light per day) were injected daily, intraperitoneally, with a further purified (ultrac$#x010B;entrifugated) pineal extract at dose levels of 0, .4 and .8 mg extractable protein per injection. The highest dose level was equal to .50 g of pineal tissue. The pineal extract had a negative linear effect (P<.001) on total litter (eight pups per litter) weight gain. The dam weight gain was not (P<.10) affected by injections of pineal extract. Litters from the 16-hr light group gained more weight (P<.10) than the 8-hr light group. The dam weight gain was higher (P<.01) for the 16-hr light group compared with the 8-hr light group. There was no interaction between light duration and administration of pineal extract.

Footnotes

1 This work was supported by the Ontario Ministry of Agr. and Food, and NRC Grant A-6247.

2 Request reprints from R. R. Hacker.

3 Present address: Norhedevej 24, Lyne 6880 Tarm, Denmark.

4 Dept. of Animal and Poultry Science.






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Copyright © 1979 by the American Society of Animal Science.