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Manganese Retention in Rats Fed Different Diets and Chemical Forms of Manganese^{1 ,2,}

University of Georgia³, Athens 30602

Abstract

The effect of chemical form and diet on manganese retention was studied in rats using two diets. The corn-skim milk low-manganese diet was fed to three groups of male, weanling albino rats and a purified manganese-free casein-dextrose diet was fed to three other groups. After 7 days on the diets one group on each diet received orally either ^{5 4}MnCl₂, MnCl₂ plus carrier manganese as MnCl₂ in the dose, or ^{5 4}MnC0₃ which contained MnC0₃ as a carrier in the dose. The third day after dosing, the rats were sacrificed and samples of liver, kidneys, semitendinosus muscle and tibia were taken for ^{5 4}Mn and stable manganese analysis.

Tissue ^{5 4}Mn contents from rats fed the insoluble carbonate form were the same as from those given soluble chloride, indicating these chemical forms did not affect manganese availability or metabolism.

Diet had a large effect on both ^{5 4}Mn and stable manganese content of the tissues. Rats fed the corn-skim milk diet had many times more s Mn and stable manganese in the tissues than did rats given the purified diet. These are extraordinary differences since homeostatic mechanisms normally keep tissue manganese levels remarkably constant. On a weight-adjusted basis, both liver and kidney weights were less in rats on the corn-skim milk diet than in rats fed the purified diet. The results show that type of diet can greatly influence the results of manganese availability and retention studies and also may overcome homeostatic mechanisms which normally keep tissue manganese levels relatively constant.

¹ This research was supported by State and Hatch funds allocated to the Georgia Agri. Exp. Sta.

² The technical assistance of Dr. R. A. McCreery, Dr. V. J. Hurst and Barbara Lawrence with X-ray diffraction apparatus is gratefully acknowledged.

³ Dept. of Animal and Dairy Science.