J. Anim Sci.
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J. Anim Sci. 1979. 49:1120-1124.
© 1979 American Society of Animal Science
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Monitoring the Effects of Selected Compounds on Feeding Behavior of Sheep1

Paul F. Duquette and Larry A. Muir

Merck Institute for Therapeutic Research2, Rabway, NJ 07065

Abstract

A system for monitoring feed intake, meal number, meal size, meal time, meal interval and total time spent eating, is described. The system was used to study the effects of cyproheptadine, an appetite stimulant; a cyproheptadine methyl piperidine analog (CMPA); MK-940, a drug that blocks norepinephrine reuptake in the brain; and insulin after im injections on the feeding behavior of wether lambs. On control days, lambs consumed an average of 1,280 to 1,570 g of feed in 12 to 15 meals averaging 102 grams. Controls averaged 5.1 to 5.6 min per meal with intervals of 1.57 to 1.96 hr between meal starts and spent 65.2 to 85.6 min per day eating. Cyproheptadine stimulated feed intake during the 3 hr after dosing (P≤.05) by increasing meal frequency (P≤.10) and total time spent eating (P<.05). Feed consumption decreased after this period, so that cyproheptadine had no net effect on 24-hr feeding parameters. Insulin and CMPA had no effect on 24-hr feed intake although insulin increased the number (P≤.10) and decreased the size (P≤.05) of meals and CMPA decreased meal size (P≤.10). MK-940 reduced daily feed intake (P≤.05) and all feeding parameters appeared to be altered for 3 hr after dosing. MK-940 reduced meal size (P≤.05) and daily time spent eating (P≤.10).

Footnotes

1 The authors wish to express their appreciation to Robert Prediger, Richard Nescot and Richard Geiger for their help in design and assembly of the electronic portion of the feed monitoring unit.

2 Department of Animal Nutrition and Physiology






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Copyright © 1979 by the American Society of Animal Science.