J. Anim Sci.
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J. Anim Sci. 1979. 49:1076-1084.
© 1979 American Society of Animal Science
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Intracranial Injections of 5-HT and db cAMP and Feeding in Sheep and Cattle

Clifton A. Baile, James S. Beyea1, Lavern F. Krabill2 and Mary Anne Della Fera

Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Kennet Square 19348

Abstract

The effect on feeding of 5-HT (5-hydroxy-tryptamine in sheep and cattle, and whether this effect could be mediated by cyclic adenosine monophosphate (cAMP) was tested. Steers (n = 8) and wethers (n = 8) were surgically prepared with lateral ventricular guides. Feed intake was increased (P<.05) by administration of 5-HT, dissolved in synthetic CSF (sCSF), into the lateral ventricles of both steers and wethers. Wethers (n = 16) prepared with hypothalamic guides were injected with 1.0 µ sCSF or 8, 32, 128, and 512 nmoles of either 5-HT or the dibutyryl derivative of cAMP (db cAMP) dissolved in synthetic CSF. Data were grouped according to injection sites based on histological examination of the brains (dorso-anterior, ventro- and dorsomedial, and anterior perifornical hypothalamus, and anterior commissure). Feeding increased following injection of 32 and 128 nmoles (263% and 257% of control, respectively) of 5-HT into the anterior commissure region, and 512 nmoles (384% of control intake) of 5-HT into the ventro- and dorsomedial hypothalamus (P<.05). Only one dose of db cAMP (8 nmoles) increased feeding and only when injected into the anterior commissure (P<.01). It is concluded that feeding occurs in response to 5-HT injected into distinct areas of the brain, but exogenous db cAMP does not consistently elicit feeding in these areas.

Footnotes

1 Present address: SmithKline Corp., 1500 Spring Garden St., Philadelphia, PA 19101.

2 Present address: The Upjohn Co., Kalamazoo, MI 49001.






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