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Gluconeogenesis in Neonatal Piglet Liver¹

Abstract

The gluconeogenic capacity of livers from day old and 5-day-old piglets has been studied. The data show infused piglets and perfused livers convert lactate to glucose. Studies with isolated liver mitochondria show a large capacity to flux pyruvate through the pyruvate carboxylase reaction causing an accumulation of malate, citrate and phosphoenolypyruvate. Factors that affect accumulation of malate, citrate and phosphoenolypyruvate are described. Infusion of day-old piglets with oleic acid for 3 hr did not affect parameters investigated. Experiments on the capacity of livers from 5 day old piglets to control glucose production from lactate in the presence of glucose at concentrations considered to be hypoglycemic (30 mg%) and hyperglycemic (300 mg%) indicate a lack of such control. Similar concentrations of 10 mM lactate were converted to glucose over a 3 hr period in these experiments.

¹ With the technical assistance of C. Lindsey. Paper No. 8155 from the Michigan State Agricultural Experiment Station. Supported by NIH grant HD-05821.

² Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824.

³ Department of Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan 48824.

⁴ Food Protein Research Center, Texas A&M University, F.E. 183, College Station, Texas 77843.