J. Anim Sci.
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J. Anim Sci. 1979. 48:1464-1469.
© 1979 American Society of Animal Science
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Oxytetracycline Absorption and Excretion in Wethers

B. D. Bradley, N. E. Alderson, W. M. Knight, J. J. Colaianne and H. H. Bryant1

Bureau of Veterinary Medicine, Food and Drug Administration, Beltsville, MD 20705

Abstract

Three trials were conducted to evaluate the absorption and excretion of oxytetracycline (OTC) in wethers. In trial 1, six wethers were given 1 g of OTC per day for 14 days orally or abomasally (via abomasal fistula) and were fed either a high or low fiber diet. OTC was detected in serum 1 and 4 hr post-dosing in abomasally and orally dosed wethers, respectively. Abomasally dosed wethers had higher (P<.01) OTC levels in serum collected serially on the first day of dosing. Wethers dosed abomasally and (or) fed a low fiber diet had higher (P<.01) OTC levels in serum collected on day 14. In the second trial, four wethers were dosed orally (via rumen fistula) and abomasally for 14 days with 1.0 g of OTC per day. The same design was used in the third trial, but 100 mg of OTC were administered per day. Route of administration in trial 2 had an effect (P<.01) on OTC levels in serum collected serially on the first day of dosing, as seen in trial 1. In trial 2, wethers dosed abomasally had higher mean fecal OTC recovery (P<.05) and 14-day serum levels (P<.01). Serum OTC levels in trial 3 were below the detectable level. While route of administration in trial 3 produced no detectable effect (P>.05) on recovery of OTC in the feces, abomasally dosed animals had higher values as was observed in trial 2.

Footnotes

1 Bureau of Drugs, Food and Drug Administration, Washington, DC 20204.






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