J. Anim Sci.
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J. Anim Sci. 1979. 48:1165-1171.
© 1979 American Society of Animal Science
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Estimation of Half-Life and Metabolic Clearance Rate of Thyrotropin-Releasing Hormone in Sheep Using a Double Antibody Radioimmunoassay1,2,

John Klindt, S. L. Davis and D. L. Ohlson3

University of Idaho, Moscow 83843

Abstract

A tripeptide, thyroptropin-releasing hormone (TRH), isolated from hypothalamic tissue has the ability to stimulate release of thyrotropin (TSH) from the pituitary both in vivo and in vitro (Schalley et al., 1966; 1968; Burgus et al., 1969). In addition, exogenous TRH also stimulates release of prolactin (PRL) in most species studied (Davis and Borger, 1972; Convey et al., 1973; Bowers et al., 1973) and, in some cases, growth hormone (GH) Convey et al., 1973; Davis et al., 1976). However, it is not known if TRH is a physiological regulator of either PRL or GH secretion. Elucidation of the physiological actions of TRH is partially dependent upon definition of its endogenous secretory pattern, which requires a sensitive and specific assay system for TRH in biological fluids. Plasma hormone concentration is a function of both secretion rate of the hormone and its rate of clearance from the circulation. The estimation of these physiological parameters is dependent upon knowledge of the kinetic parameters of plasma metabolic clearance rate (MCR), and circulating half-life (t1/2) of the hormone.

Footnotes

1 Idaho Agricultural Experiment Station Pub. No. 78410.

2 These studies were conducted in partial fulfillment of the requirements for the PH.D. degree at Washington State University under support by the University of Idaho Agricultural Experiment Station, and in part by grants from the National Institutes of Health (HD 07830) and, Merck Institute for Theraputic Research, Rahway, NJ.

3 Department of Animal Sciences.






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