J. Anim Sci.
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J. Anim Sci. 1978. 47:1314-1323.
© 1978 American Society of Animal Science
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Concentrations of Prostaglandins E2 and F2{alpha} and Their Relationship to Luteal function in Early Pregnant Ewes1

G. S. Lewis2, P. E. Jenkins, R. L. Fogwell3 and E. K. Inskeep

West Virginia University, Morgantown 26506

Abstract

The effects of early pregnancy on tissue concentrations of prostaglandins E2 and F2{alpha}: (PGE2 and PGF2{alpha}) in the ovine endometrium, uterine vein and ovarian artery and on concentrations of PGE2 and PGF2{alpha} in uterine venous plasma were examined. The relationship of concentrations of progesterone in jugular plasma to concentrations of PGE2 and PGF2{alpha} in uterine venous plasma was determined. A uterine branch of the ovarian vein (UBOV) adjacent to an ovary bearing a corpus luteum was cannulated on day-14 postestrus in four pregnant and five nonpregnant ewes. Blood was collected from the UBOV of each ewe at 30-min intervals during each of five collection periods lasting approximately 1 hr (three blood samples per period; 15 per ewe). The first collection of blood from the UBOV was initiated at 0700 hr on day-15 postestrus. Each successive collection period was initiated approximately 6 hr after the start of the previous period. A jugular blood sample was taken from each ewe immediately after each sample from the UBOV. Samples of endometrium, uterine vein and ovarian artery were collected from each ewe on the morning of day-16 postestrus.

The overall mean concentrations (ng/ml) of PGE2 (.7 ± .1 vs 1.2 ± .2) and PGF2{alpha} (3.3 ± .4 vs 4.4 ± .9) in plasma from the UBOV and progesterone (3.1 ± .1 vs 2.4 ± .1) in jugular venous plasma did not differ in pregnant and nonpregnant ewes. Profiles of PGE2 did not differ with pregnancy status. Profiles of PGF2{alpha} differed over the 24-hr period studied (pregnancy status x collection period; P<.05), but not within the collection periods. Concentration of progesterone decreased significantly over time (P<.05) and collection periods (P<.01) in the nonpregnant ewes, but showed no covariance with concentrations of PGF2{alpha} and PGE2 in pregnant or nonpregnant ewes.

Concentrations of PGE2 and PGF2{alpha} in endometrium and uterine venous tissue and PGF2{alpha} in ovarian arterial tissue were not affected by pregnancy status. In ovarian artery there tended to be less PGE2 in nonpregnant than in pregnant ewes (P<.01).

Footnotes

1 Published with the approval of the Director of the Agricultural Experiment Station as Scientific Paper No. 1543. Supported by project Hatch 224 (NE-72) from the Division of Animal and Veterinary Sciences. The authors gratefully acknowledge Bruce Pratt and Drs. R. L. Butcher and R. A. Dailey for valuable discussion in the planning of the experiment and preparation of the manuscript; and assistance in statistical analysis by Dr. W. V. Thayne.

2 Present address: Department of Dairy Science, University of Florida, Gainesville 32611.

3 Present address: Department of Dairy Science, Michigan State University, East Lansing 48824.






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Copyright © 1978 by the American Society of Animal Science.