J. Anim Sci.
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J. Anim Sci. 1978. 47:923-926.
© 1978 American Society of Animal Science
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Effect of Prostaglandin E2 and F2{alpha} on Serum Luteinizing Hormone, Testosterone and Prolactin in Bulls1

N. B. Haynes2, R. J. Collier3, T. E. Kiser4 and H. D. Hafs5

Michigan State University, East Lansing 48824

Abstract

The effect of intramuscular injections of PGF2{alpha} and PGE2 on concentrations of testosterone, luteinizing hormone and prolactin were examined in 1-year-old bulls. Jugular venous blood was sampled from indwelling cannulae at frequent intervals before and after injecting 0, 5, 15 or 30 mg PGE2 or 30 mg PGF2{alpha} in five bulls. Treatments were administered in a Latin-square design. Both PGF2{alpha} and 30 mg PGE2 caused increased serum prolcatin concentrations within 10 min; prolactin concentrations remained elevated longer after PGF2{alpha} than after PGE2. Peak prolactin after 15 mg was only half that after 30 mg PGE2 and the change in prolactin was not significant after 5 mg PGE2. While PGF2{alpha} caused significant elevations in serum testosterone and luteinizing hormone (LH), each of these hormones was depressed for 4 to 5 hr by each dose of PGE2. Normal episodic secretion of LH and testosterone resumed within 8 hr after PGE2 treatment. We conclude PGE2 acutely inhibited release of LH.

Footnotes

1 Michigan Agricultural Experiment Station Journal Article No. 8503. This research was supported in part by USPHS Research Grant No. HD 06948. PGF2{alpha} Tromethamine salt and PGE2 were kindly provided by Dr. J. W. Lauderdale, The Upjohn Co. The Milk Marketing Board of England provided a travel grant for N. B. H.

2 Present address: Department of Physiology and Environmental Studies, University of Nottingham School of Agriculture, Sutton Bonington, N. Loughborough, Leicestershire LE12 5RD, England.

3 Present address: Dairy Science Department, Universtiy of Florida, Gainesville 32611.

4 Present address: Department of Animal and Dairy Science, University of Georgia, Athens 30602.

5 Animal Reproduction Labortory, Department of Dairy Science.






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Copyright © 1978 by the American Society of Animal Science.