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Local Effect of Intrauterine Devices on Prostaglandin F₂ in Uterine Venous Plasma of Gilts¹

West Virginia University, Morgantown 26505

Abstract

The effect of an intrauterine device (IUD) on uterine release of PGF₂ was studied in gilts. An IUD (15 x 75 mm plastic coil) was inserted at the mid-point of one uterine horn on day 3 of an estrous cycle in seven gilts and inserted and removed immediately in six sham-operated gilts. At relaparotomy on day 6, uterine venous blood samples were collected from uterine branches of the ovarian veins draining three separate sites of the uterine horns. One sample was from the area of the uterine horn that received the IUD or sham operation, one anterior to the IUD site on the same uterine horn and one at the midpoint of the opposite uterine horn. These plasma samples were radioimmunoassayed for PGF₂. Estrous cycle lengths of gilts which received an IUD (20.1 ± .5 days) were not different from those of the sham-operated gilts (24.1 ± 2.6 days; P>.1). Values for PGF₂ exhibited heterogeneity of variance among groups. At the IUD site, mean concentration of PGF₂ (ng/ml) was 14.0 ± 7.3 in IUD-treated gilts and 3.6 ± 1.7 in sham-operated gilts. When one high value at the IUD site (57 ng/ml) was excluded from analysis, variances were not heterogeneous and concentration of PGF₂ at the IUD site (7.1 ± 1.9) was higher than in the control gilts (3.6 ± 1.7; treatment x site interaction, P>.01). The concentration of PGF₂ in uterine venous plasma collected from the midpoint of the opposite uterine horn (4.2 ± .9 vs 2.5 ± 1.0) or anterior to the IUD on the same horn (2.0 ± .9 vs 3.4 ± 1.6) were not different between IUD-treated and sham-operated gilts, respectively. An IUD has a very localized stimulatory effect on uterine synthesis of PGF₂ in gilts

¹ Published with the approval of the Director of the Agricultural Experiment Station as Scientific Paper No. 1535. Supported by Hatch Project 224 (NE-72) from the Division of Animal and Veterinary Sciences, West Virginia University.