HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hwang, P. T. Articles by Antonik, A. Search for Related Content PubMed PubMed Citation Articles by Hwang, P. T. Articles by Antonik, A.

Blood Creatine Kinase as a Predictor of the Porcine Stress Syndrome¹

University of Minnesota, St. Paul, 55108 and and Antonik Laboratories, Elk Grove Village, IL 60007

Abstract

Gilts, barrows and boars of Pietrain (P), Yorkshire (Y) and P-Y-Hampshire (H) breeding, Px P (PHY), were used to study accuracy of prediction of susceptibility to the porcine stress syndrome (PSS) by the luciferase method for blood creatine kinase (CK). At 10 weeks of age, pigs were classified as PSS if they displayed muscle rigidity within 5 min after commencing anesthesia with 3% halothane in oxygen. At 28 weeks, blood was obtained 8 hr after exercise, CK determined, and the CK value used to retrospectively predict PSS classification (PSS+ or PSS—) as determined by the halothane test. For Yorkshire pigs (all PSS—) the mean CK level was 395 IU/liter. Therefore, for purposes of classifying pigs as PSS or normal via the blood CK level, 400 IU/liter was selected as the upper limit of classification of pigs as normal. A true positive outcome was defined as a PSS pig (halothane-induced rigidity) which displayed a CK value greater than 400 IU/liter blood. A normal pig (PSS— by halothane test) with greater than 400 IU/liter was considered a false positive. The number of true positive, false positive, true negative and false negative outcomes were as follows: for P-77, 6, 0 and 4; for Y-O, 8, 18 and 0; for Px P (PHY)-7, 5, 8 and 0; for all groups-84, 19, 26 and 4, respectively. Prevalence of PSS-susceptibility, based on response to halothane exposure, was 89, 0, 35 and 63% for P, Y, Px P (PHY) and all groups, respectively. Accuracy of prediction [(number correct ÷ total) x 100] of PSS-susceptibility by blood CK was 89, 69, 75 and 83% for P, Y, Px P (PHY) and all groups, respectively. The results of this study would suggest that the luciferase procedure for blood CK is a useful screening method for PSS. The efficacy of the method is influenced by prevalence of PSS in the breed being studied.

¹ Scientific Journal Series Paper No. 10,170, Minnesota Agricultural Experiment Station. Presented at the 11th Annu. Meeting, Midwestern Section, ASAS, Jan. 5–6, 1978, Southern Illinois Univ., Carbondale.

² Department of Food Science and Nutrition.

³ Department of Veterinary Clinical Science.

⁴ Department of Animal Science.

⁵ Antonik Laboratories, P.O. Box 15, Elk Grove Village, IL 60007.

This article has been cited by other articles:

				J.D. Cloke, E.A. Davis, J. Gordon, P.B. Addis, and C.J. McGrath Water Loss Rates and Temperature Profiles in Dry Heated Normal and PSE Porcine Muscle Family and Consumer Sciences Research Journal, March 1, 1981; 9(3): 240 - 250. [Abstract]