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Requirement for Selenium (as Selenite) and Vitamin E (as -Tocopherol) in Weaned Pigs:¹ III. The Effect on the Development of the VESD^,2 Syndrome of Varying Selenium Levels in a Low-Tocopherol Diet

Royal Veterinary College, S-750 07 Uppsala 7, Sweden and and College of Veterinary Medicine, SF-00550 Helsinki 55, Finland

Abstract

An experiment was run comprising 30 weaned pigs in six groups. The basic diet contained traces of selenium (8 µg/kg dry solids) and tocopherol (1.4 mg -tocopherol/kg dry solids). Control pigs and pigs given low supplements of selenium and tocopherol died or were killed in a moribund condition within a month or slightly more, showing the typical lesions of the vitamin E and selenium deficiency (VESD) syndrome. A combination of 5 mg DL--tocopheryl acetate/kg diet and 13 5 µg selenium/kg diet proved to provide protection against the syndrome. These two supplements are inadequate when administered separately.

¹ Supported by the Swedish Council for Forestry and Agricultural Research.

² Vitamin E and selenium deficiency.

³ Department of Animal Nutrition and Hygiene, Uppsala.

⁴ Department of Biochemistry, Helsinki.

⁵ Department of Pathology, Uppsala.

⁶ Department of Medicine I, Uppsala.