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Clinical and Endocrine Response of Dairy Cows with Ovarian Cysts to GnRH and PGF₂^{1 ,2,}

University of Missouri⁴, Columbia 65201

Abstract

Thirty-two Holstein and Guernsey cows diagnosed as having ovarian cysts via rectal palpation were assigned according to breed to one of four grops (eight cows/group). Treatments were: Group I — sterile water; Group II — 100 µg gonadotropin releasing hormone (GnRH); Group III — 25 mg prostaglandin F₂ (PGF₂; 33.5 mg PGF₂ Tham salt); and, Group IV - 25 mg PGF₂ 9 days following 100 µg GnRH.

Positive response (ovulation detected within 30 days following initiation of treatment) for cows in Group II (6/8), III (5/8) and IV (7/8) was not different; however, all were different (P<.01) from Group I (0/8). Mean time from initiation of treatment to estrus or silent estrus (the day prior to ovulation without estrus) was less (P<.05) in Group III (5.6 ± 2.4 days) than Group IV (12.3 ±1.2 days) and both Groups III and IV had fewer (P<.01) days to estrus or silent estrus than Group II (19.0 ±1.5 days).

In the cows that responded to treatment in Groups II and IV, an increase (P<.05) in progesterone concentrations was detected by 9 days following treatment. Within 12 hr following PGF₂ in Group IV, progesterone concentrations had declined (P<.05) from 1.5 ng/ml to .6 ng/ml and the cystic structure was not detected at the subsequent estrus or silent estrus. Positive responses for cows in Group III were variable and not easily discernible.

In summary, data in this study indicate that the luteinized ovarian cyst is responsive to the luteolytic effects of PGF₂ and PGF₂ 9 days following GnRH appeared to be the most desirable treatment for ovarian cysts.

¹ Journal Paper No. 7871, Missouri Agriculture Experiment Station, University of Missouri-Columbia. Approved by the Director. This research was conducted as part of regional research project NC-113, Methods for Improvement of Fertility in Cows Postpartum. The authors express appreciation to Janet Liebert for assistance with hormone assays and to Phyllis Kuschel for secretarial assistance in typing of the manuscript.

² This investigation was supported in part by Biomedical Research Support Grant RR07053 from the General Research Support Branch, Division of Research Resources, Bureau of Health Professions Education and Manpower Training, National Institutes of Health.

³ Present address: Animal Genetics Laboratory, Department of Animal Science, University of Illinois, Urbana, 61801.

⁴ Department of Dairy Husbandry and Department of Veterinary Medicine and Surgery.

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