J. Anim Sci.
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J. Anim Sci. 1978. 46:436-442.
© 1978 American Society of Animal Science
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Comparison of Testosterone and Androstenedione Secretion in Bulls Given Prostaglandin F2{alpha} or Luteinizing Hormone1

T. E. Kiser2, R. A. Milvae3, H. D. Hafs, W. D. Oxender and T. M. Louis4

Michigan State University, East Lansing 48824,5

Abstract

In an experiment of latin square design each of six young bulls was given at 24-hr intervals 1) saline subcutaneously (sc) as a control, 2) 200 µg luteinizing hormone (LH) intravenously (iv), 3) 20 mg prostaglandin F2{alpha} (PGF2{alpha}) sc, 4) LH plus PGF2{alpha}, 5) LH plus PGF2{alpha} 1.5 hr later or 6) PGF2{alpha} plus LH 1.5 hr later. Jugular blood was sampled at frequent intervals during the experiment. Serum LH as measured by area under the response curve was greater after LH than after PGF2{alpha} treatment. Serum testosterone increased significantly after LH or PGF2{alpha}, but the increase was greater (P<.05) after administration of PGF2{alpha} alone than after LH or after simultaneous administration of LH plus PGF2{alpha}. Serum androstenedione was significandy correlated with testosterone after episodic secretion of LH and after exogenous LH or PGF2{alpha}. Based on these observations, we suggest that LH release after PGF2{alpha} administration may not be the only action of PGF2{alpha} in causing testosterone secretion in bulls.

Footnotes

1 Published with the approval of the Director of the Agricultural Experiment Station as Journal Article No. 7952. This research was supported in part by USPHS Research Grant No. HD 06948. Dr. J. W. Lauderdale (The Upjohn Co.) supplied the PGF2a THAM salt and NIH-LH-B8 was provided by the NIH Hormone Distribution Officer. Adrenalectomized steer plasma was provided by W. C. Wagner, Iowa State University.

2 Present address: Dept. Animal and Dairy Science, Univ. of Georgia, Athens.

3 Present address: Dept. Animal Science, Cornell Univ., Ithaca, NY.

4 Present address: Dept. Anatomy, East Carolina Medical School, Greenville, NC.

5 Animal Reproduction Laboratory, Department of Dairy Science.






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Copyright © 1978 by the American Society of Animal Science.