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Insulin and Glucose Effects on Amino Acid Metabolism in Pregnant and Nonpregnant Ewes^{1 ,2,}

U.S. Department of Agriculture and University of Nebraska^,5, Clay Center, NB 68933

Abstract

The effects of 1) a rapid intravenous injection of insulin (4.4 IU), 2) a continuous intravenous infusion of insulin (.14 IU/min), or a rapid intravenous injection of glucose (.24 g/kg body weight) into nonpregnant ewes and a continuous intravenous infusion of glucose (1.2 mg/kg body weight/min) into pregnant ewes on plasma amino acid metabolism and -amino acid nitrogen (-NH₂-N) uptake by the gravid uterus were studied in four experiments. A continuous infusion or a rapid injection of insulin into nonpregnant ewes did not significantly alter total plasma free -NH₂-N or plasma urea-N concentrations. Plasma glucose concentrations decreased to about 50% of control levels with both continuous and rapid insulin infusions. However, total plasma free -NH₂-N decreased with a rapid injection of glucose into nonpregnant ewes and a continuous infusion of glucose into pregnant ewes. Concentrations of lysine, arginine, threonine, leucine, and tyrosine decreased most markedly (about 35%) after rapid glucose injection. Continuous glucose infusion into pregnant ewes did not markedly alter blood flow to or -NH₂-N uptake by the gravid uterus.

¹ Published as Paper No. 5149, Journal Series, Nebraska Agricultural Experiment Station, Lincoln.

² Appreciation is expressed to Mr. R. Mlejne, Ms. S. Rothfuss and Ms. B. DeChiaro for assistance with the laboratory analyses, to Mr. B. Larsen for the care of experimental animals.

³ U.S. Meat Animal Researcher Center, Agricultural Research Service.

⁴ Department of Animal Science, University of Nebraska, U.S. Meat Animal Research Center.

⁵ Mention of a trade name, proprietary product, or specific equipment does not constitute a guarantee or warranty by the U.S. Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.