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Requirement for Selenium (as Selenite) and Vitamin E (as -Tocopherol) in Weaned Pigs¹. II. The Effect of Varying Selenium Levels in a Vitamin E Deficient Diet on the Development of the Vesd Syndrome^,2

Royal Veterinary College, S-750 07 Uppsala 7 and Sweden and College of Veterinary Medicine, SF-00550 Helsinki 55, Finland

Abstract

An experiment comprising five groups of a total of 25 weaned pigs was performed, using a basic diet deficient in selenium (8.0 ± .9 µ/kg dry solids, d.s.) and vitamin E (1.4 mg -to-copherol/kg d.s.). Selenium in the form of sodium selenite was added, namely 5, 15, 45 and 135 µ/kg food.

The pigs which received no supplements or supplements up to and including 15 µ/kg died within 4 weeks. The pigs which received 45 µ/kg or 135 µ/kg survived for 3 1/2 months, when they were killed and necropsied. However, no complete protection was achieved, as elevation of serum aspartate aminotransferase (ASAT), attacks of cutaneous microangiopathy (MAP), and pathologic lesions characteristic of the vitamin E and selenium deficiency (VESD) syndrome were observed in all groups.

¹ Supported by the Swedish Council for Forestry and Agricultural Research.

² Vitamin E and selenium deficiency.

³ Department of Animal Nutrition and Hygiene, Uppsala.

⁴ Department of Pathology, Uppsala.

⁵ Department of Medicine I, Uppsala.

⁶ Department of Biochemistry, Helsinki.