HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Olsen, R. F. Articles by Gahagan, J. H. Search for Related Content PubMed PubMed Citation Articles by Olsen, R. F. Articles by Gahagan, J. H.

Effects of Zeranol on Blood Metabolites and Hormones in Wether Lambs^{1 ,2,}

The Pennsylvania State University, University Park 16802

Abstract

Three experiments were conducted to determine the effects of zeranol on blood metabolites and hormones in wether lambs. Intravenous infusion of 0, 1 or 5 mg zeranol in Experiment 1 did not affect serum urea nitrogen, glucose, growth hormone (GH) or insulin. Implantation with 12 mg zeranol in Experiment 2 increased serum GH and insulin, but did not change serum urea nitrogen or glucose. In Experiment 3, wether lambs implanted with 0, 12 or 96 mg zeranol were infused with .5 g/kg body weight of arginine. Clearance rate of the arginine was not affected by implantation. Insulin secretion in response to arginine was not influenced by zeranol implantation. Because arginine failed to stimulate GH release, no conclusions could be drawn concerning GH secretory capacity of the pituitary. In summary, zeranol did not affect serum urea nitrogen or glucose in any experiment. Serum GH and insulin were increased by zeranol implantation but not by zeranol infusion. These data suggest that chronic exposure to zeranol was necessary to stimulate an increase in serum GH and insulin in wethers.

¹ Authorized for publication on June 1, 1976, as Paper No. 5095 in the Journal Series of the Pennsylvania Agriculture Experiment Station.

² Supported in part by IMC Chemical Group, Inc. Terre Haute, IN 47808.

³ All authors are affiliated with the Department of Dairy and Animal Science.