J. Anim Sci.
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J. Anim Sci. 1977. 45:1091-1095.
© 1977 American Society of Animal Science
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Response of Bovine Ovarian Arterial Smooth Muscle to Prostaglandin F2{alpha} and Neurotransmitter1

S. P. Ford2, L. J. Weber3, W. H. Kennick2 and F. Stormshak2

Oregon State University, Corvallis, 97331

Abstract

A segment of artery supplying each ovary was removed from eight beef heifers on day 17 of the estrous cycle (estrus = day 0), noting which artery was ipsilateral and which was contralateral to the ovary containing the largest follicle and greatest amount of follicular fluid. In five of eight heifers, the ovary with the greater follicular development also contained the corpus luteum. Each arterial segment was perfused with oxygenated Krebs Henseleit solution prior to initiating sequential 10-min perfusions of saline and agents which enhance (prostaglandin F2{alpha} and norepinephrine) or suppress (phentolamine) vasoconstriction. At the end of each perfusion, vasoconstriction was provoked by periarterial nerve stimulation (NS). Prostaglandin F2{alpha}-tromethamine salt (PGF2{alpha}, 1 ng salt/ml) only enhanced constriction of ipsilateral arteries (P<.01). Although perfusion of norepinephrine (NE, 500 ng/ml) increased constriction of both ipsilateral and contralateral arteries (NE vs saline, P<.01, respectively), the response of ipsilateral arteries to this neurotransmitter exceeded (P<.01)that of contralateral arteries. Phentolamine (100 ng/ml) blocked constriction of all arteries to NS (P<.01). Subsequent perfusion of PGF2{alpha} and NS failed to elicit an increase in constriction over that following the perfusion of phentolamine. Perfusion of NE after PGF2{alpha} displaced bound phentolamine and resulted in only ipsilateral arteries responding to NS with increased constriction (P<.01). These data suggest that ovarian function markedly influences the ability of the ipsilateral ovarian artery to respond to vasoconstrictors.

Footnotes

1 Technical Paper No. 4455, Oregon Agricultural Experiment Station.

2 Department of Animal Science.

3 Department of Pharmacology.






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Copyright © 1977 by the American Society of Animal Science.