J. Anim Sci.
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J. Anim Sci. 1977. 45:1032-1036.
© 1977 American Society of Animal Science
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Microscopic Observations of Muscle from Swine Susceptible to Malignant Hyperthermia1

E. G. Palmer2, D. G. Topel3 and L. L. Christian3 ,4,

Iowa State University, Ames 50011

Abstract

Light and electron microscopic observations were made on muscle from pigs classified as malignant hyperthermia (MH) susceptible by their reaction to halothane anesthesia. Littermate MH resistant pigs served as controls. Both the lateral biceps femoris and the longissimus muscle of MH susceptible pigs contained a higher (P<.05) proportion of cells with supercontractions (30.1%) than did muscle from resistant animals (7.6%). The longissimus muscle of MH susceptible pigs also contained a higher percentage of internal (central) nuclei than did the other muscles sampled. Muscle of MH susceptible animals did not differ from control muscle in other histological and ultrastructural features.

Footnotes

1 Journal Paper No. J-8767 of the Iowa Agriculture and Home Economics Experiment Station, Ames. Projects 2008 and 1901. Research supported in part by PHS/NIH Grant No. 5 S05RR 07034-09 and by USDA CSRS grant 616-15-153.

2 Department of Veterinary Anatomy, Pharmacology and Physiology, College of Veterinary Medicine.

3 Department of Animal Science, College of Agriculture.

4 The authors acknowledge the advice of Paul N. Hinz on the statistical analyses, and the technical laboratory assistance of Barbara D. Lee.






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Copyright © 1977 by the American Society of Animal Science.