J. Anim Sci.
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J. Anim Sci. 1977. 45:768-775.
© 1977 American Society of Animal Science
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Effects of Pseudopregnancy and Ergocornine Treatment on Synchronization of Mating, Duration of Gestation and Production of Young in Rats

D. R. Bennett, R. P. Rathmacher and R. L. Cochrane1

Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46206

Abstract

Cyclic and pseudopregnant rats were treated with ergocornine hydrogenmaleate (1 mg), to evaluate the use of induced luteolysis as a method for synchronizing mating. Pseudopregnancy in non-treated rats was found to decrease the degree of mating synchronization, prolong gestation and decrease the number of young born per pregnant female. Ergocornine treatment of both cyclic and pseudopregnant rats decreased pregnancy rate. Ergocornine treatment of pseudopregnant rats also increased the degree of synchronization in mating, decreased the length of gestation and increased the number of young and placental scars per pregnant female. It had little effect on these end-points when given to cyclic rats. Length of gestation was negatively correlated (P<.001) with number of young, live young and placental scars (r=–.53, –.58 and –.47, respectively; n=96).

Footnotes

1 We would like to thank Dr. R. L. Elton, Sandoz Pharmaceuticals, Hanover, NJ, for the generous gift of ergocornine hydrogenmaleate used in this study. We are also indebted to Dr. L. E. Casida, University of Wisconsin, Dr. D. M. Brennan, Dr. R. J. Kraay, Mr. F. C. Tinsley and Dr. J. F. Wagner, Eli Lilly and Company, for helpful advice and suggestions and to Mr. J. G. Powell, Jr. and Mr. E. B. Smalstig for technical assistance.






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Copyright © 1977 by the American Society of Animal Science.