HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lillie, R. J. Articles by Graber, G. Search for Related Content PubMed PubMed Citation Articles by Lillie, R. J. Articles by Graber, G.

Effect of Dietary Copper and Tylosin and Subsequent Withdrawal on Growth, Hematology and Tissue Residues of Growing-finishing Pigs

Nutrition Institute, Beltsville, MD 20705 and and Food and Drug Administration, Bureau of Veterinary Medicine, Beltsville, MD 20705

Abstract

Early-weaned pigs were fed 0, 125, 250 and 500 ppm copper with or without 55 ppm tylosin supplement through 50 kg body weight and thereafter a standard finisher diet through 100 kg body weight. Blood samples were collected at 10, 30, 50, 60, 75, 80 and 100 kg body weights for copper analyses; liver, kidney and loin samples were obtained for copper analyses from randomly selected pigs sacrificied at 50, 75 and 100 kg body weights. Average daily gain and feed/gain were significantly depressed by 250 and 500 ppm copper, while tylosin effects were significant for average daily gain from initial to 10 kg body weight. Hemoglobin and hematocrit values were significantly decreased by 250 and 500 ppm supplemental copper beginning with 30 and 10 kg body weight, respectively. Recovery was rapid after copper withdrawal. Tissue copper residues were greatest in liver, intermediate in kidneys and lowest in longissimus and plasma at 50 kg body weight. The differences were significant for liver and kidneys when compared with those of controls. Although not significant, the tissue copper concentration was higher in presence than in absence of tylosin, especially for liver and kidneys at 50 kg body weight. Residue copper in the longissimus and blood plasma remained unchanged. After supplemental copper withdrawal, a drastic reduction in residue copper was noted for liver and kidneys; however, the differences were significant for liver only. Tylosin effects were nonsignificant for residue copper despite the increased copper concentration in liver and kidneys at 50 and 75 kg body weights and in liver at 100 kg body weight.

The results suggest that, if copper is to be included in grower swine diets, the supplemental copper level for maximum average daily gain, feed/gain, hematology and residue copper in tissues should not exceed 125 ppm and should be restricted to pigs under 50 kg body weight.

¹ U.S. Department of Agriculture, Nonruminant Animal Nutrition Laboratory

² Department of Health, Education and Welfare.

³ The authors express gratitude for the valuable statistical services rendered by Dr. Bernie Weinland of the Biometrical Services Staff, A.R.S., U.S.D.A., Beltsville, MD 20705

This article has been cited by other articles:

				M. E. Davis, C. V. Maxwell, D. C. Brown, B. Z. de Rodas, Z. B. Johnson, E. B. Kegley, D. H. Hellwig, and R. A. Dvorak Effect of dietary mannan oligosaccharides and(or) pharmacological additions of copper sulfate on growth performance and immunocompetence of weanling and growing/finishing pigs J Anim Sci, November 1, 2002; 80(11): 2887 - 2894. [Abstract] [Full Text] [PDF]