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Accumulation of Myofiber Nuclei in Pigs with Normal and Arrested Development¹

University of Guelph², Guelph, Ontario, Canada

Abstract

The accumulation of myofiber nuclei in the porcine sartorius muscle was studied by counting the numbers of nuclei appearing in transverse histological sections. On the basis of animal age, the accumulation of nuclei in transverse sections described a sigmoid curve, rising to a maximal rate of accumulation at 80 days (postnatal) and declining thereafter. Using the myofiber growth data of other researchers, it was shown that the accumulation of myofiber nuclei in transverse sections was closely related to radial myofiber growth. When animals were placed on a low plane of nutrition to arrest growth, nuclear accumulation was only affected at, or prior to 80 days. Microspectrophotometric measurements of the deoxyribonucleic acid content of individual myofiber nuclei stained by the Feulgen reaction revealed no evidence of amitosis (nuclear fragmentation) during normal growth.

¹ Research supported by the Ontario Ministry of Agriculture and Food, project number A-03-599. The experimental material for the study was generously provided by Professor L. G. Young.

² Department of Animal and Poultry Science.