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Influence of Bambermycins on Salmonella Infection and Antibiotic Resistance in Calves¹

Litton Bionetics, Inc., Kensington, MD 20795 and Hoechst-Roussel Pharmaceuticals Inc., Somerville, NJ 08876

Abstract

Fourteen 8-week-old calves infected with S. typhimurium were fed control and 10 mg/ head/day bambermycins in an 8-week study to determine the effect on quantity, prevalence, shedding and susceptibility of Salmonella. Special precautions were taken to eliminate cross-contamination between infected and uninfected animals on both treatments.

Salmonella counts of the homogenized fecal samples were monitored to study the parameters before and after inoculation. Five colonies from each fecal specimen suspected of being Salmonella were isolated, serologically identified and tested for susceptibility to 10 antibiotics.

The use of bambermycins supplemented feed reduced the duration and prevalence of Salmonella shedding in calves. Bambermycins fed calves showed a significant decrease in the number of Salmonella shed during the first 7 days, and throughout the trial the quantity of Salmonella shed was less. Furthermore, feeding bambermycins diets significantly reduced the number of Salmonella resistant to streptomycin, ampicillin, and oxytetracycline.

¹ We gratefully acknowledge the technical assistance of Eva Barrion. Thanks are also due to Charles Riggs and his staff for the statistical analyses.