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Fate of Tritium in Calves Subcutaneously Implanted with ³ Diethylstilbestrol^,1

Institut National de la Recherche Agronomique Laboratoire de Recherches, sur les Additifs Alimentaires, Toulouse, France

Abstract

Tritiated diethylstilbestrol (DES) was subcutaneously implanted in two young calves at 2, 5 and 61 days of age. The excretion patterns of radioactivity and levels in urine, feces and blood were measured over 98 days. Residual levels of radioactivity in saliva, tissues and organs were determined at slaughter. Radioactivity was 10 times higher in feces dry matter than in undried urine and blood. Feces radioactivity was almost completely associated with free DES. Feces may be the most suitable sampling material at slaughter for reliable DES detection.

¹ This work was partly supported by French government (D.G.R.S.T.—D.A.T.A.R. Grant No. 73.7.1880). The authors kindly acknowledge M. Rigaud and P. Dubois, Station de Technologie des Produits végétaux, I.N.R.A., Dijon, France, for the GLC-MS study.

³ École Nationale Vétérinaire, Chaire de Nutrition et Alimentation, 94 701 Maisons-Alfort, France.

² Institut National de la Recherche Agronomique, Laboratore de Recherches sur les Additifs Alimentaires, 180, chemin de Tournefeuille, 31 300 Toulouse, France.