J. Anim Sci.
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J. Anim Sci. 1976. 43:786-791.
© 1976 American Society of Animal Science
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Influence of Dietary Treatment on Rat Carcass DDT Residues and Toxicity Parameters1

W. L. Martin2,3,, R. W. Rogers4, H. W. Essig4, H. W. Chambers5 and L. B. Coons6

Mississippi State University, Mississippi State 39762

Abstract

The total edible portion of carcasses of two steers that had been fed cotton gin trash contaminated with DDT was broiled and the broiled ground beef, less fat drippings, was fed to rats for 120 days. There were no differences (P>.05) in carcass DDT residues of rats fed ground beef from steers that initially contained either 7.55 ppm of DDT (above FDA tolerance) or 4.25 ppm (within FDA tolerance) of DDT on a rendered fat basis. The addition of .5% choline chloride to ground beef diets did not alter (P>.05) total DDT residue in rat carcasses. There was a sex by treatment interaction (P<05) for rats fed the High diet (1.24 ppm DDT as fed) plus .5% choline chloride (High + CC), the Low diet (.45 ppm DDT as fed) plus p,p-DDT (Low + DDT) and the High diet plus p,p-DDT (High + DDT). In all three treatments, females retained more DDT residues than did males. Females fed the High + DDT diet and the High + CC diet retained more (P<05) total DDT than did rats in all other treatments.

Two parameters were utilized to determine primary effect of DDT ingestion. They were mixed function oxidase (MFO) activity and the development of smooth endoplasmic reticulum (SER) in rat livers. MFO activity appeared to increase with ingestion of DDT in the all meat diets but was lower than MFO activity for rats fed the control diet. Electron microscopy examination of liver samples revealed no SER proliferation in livers of rats fed DDT when compared to livers from rats fed no DDT.

Footnotes

1 Mississippi Agricultural and Forestry Experimental Station Journal Article No. 3207

2 Data taken from a dissertation submitted in partial fulfillment of the requirements for a Ph.D. degree at Mississippi State University

3 Mississippi Department of Agriculture

4 Department of Animal Science

5 Department of Entomology

6 Electron Microscopy Center






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Copyright © 1976 by the American Society of Animal Science.