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Effect of Age, Weaning and Diet on Swine Adipose Tissue and Liver Lipogenesis¹

Shell Development Company, Biological Sciences Research Center², Modesto, California 95352 and and University of Nebraska, North Platte Station, North Platte 69101

Abstract

In previous studies utilizing nursing pigs (no creep feed), the adipose tissue lipogenic rate was suppressed up to postpartum day 35. The present studies, designed to remove the variability of individual sow milk production, employed artificial rearing and consequent control of the diet composition. In all but one experiment, the lipogenic rate increased with chronological age. Thus, a high fat intake (milk replacer or high-fat weaning diet) fed for 2 to 5 weeks and studied in animals at postpartum ages from 4 to 8 weeks did not suppress adipose tissue lipogenesis measured as carbon flux from glucose or as any of several key enzymes in the pathway. Since the lipogenic rate was increased with chronological age, regardless of diet, factors other than the fat content of the diet appear to be implicated.

Swine liver lipogenesis was extremely low when assessed with a variety of in vitro incubation conditions and substrates. There was also no enhancement of this activity in animals exposed to several dietary conditions or at numerous ages. Lactate was the only substrate incorporated to any extent into hepatic fatty acids; however, this activity may not represent de novo synthesis but rather chain elongation.

¹ We wish to thank M. C. Arakelian for the lipid analysis, F. Gonsalves and R. A. Presant for excellent care of the animals, and Dr. D. E. DeKay for the design of the diets utilized in experiment 4.

² Mailing Address: Shell Development Company, Biological Sciences Research Center, P. O. Box 4248, Modesto, California 95352.

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