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The Upjohn Company, Kalamazoo, Michigan 49001
Abstract
Five experiments involving 768 crossbred swine, averaging 29.9 lb (13.6 kg) live weight, were conducted to determine the effective level or levels of lincomycin (L) required for the treatment and control of swine dysentery. All levels of L, ranging from 20 to 130 g/T (22 to 144 mg/kg) of feed, resulted in significant reduction of clinical signs of dysentery and improvement in daily gain and gain/feed, when compared with controls.
The minimum amount of lincomycin required for maximum treatment of the disease was 100 g/T (110 mg/kg) of feed. A lincomycin concentration of 40 g/T (44 mg/kg) was considered as the least amount of antibiotic which would be effective even though 20 g/T (22 mg/kg) was more efficacious than no medication. Therefore the most effective range of lincomycin for the treatment and control of swine dysentery was 40 to 100 g/T (44 to 110 mg/kg) of feed.
1 The authors acknowledge support from Drs. R. E. Bloss and E. F. Nicks, and technical assistance of L. W. Mohney and R. A. Evans of The Upjohn Company. Gratitude is also extended to Dr. J. A. Firth, Field Specialties Co., Des Moines, Iowa, Frank Hussey, National Field Research, Truman, Minnesota, and to Drs. J. Kunesh and D. L. Harris, Iowa State University, Ames, for assistance during conduct of these experiments.
2 Feed Additives and Parasitology, Unit 9660-190-1.
3 Present address: Transagra Corp., 5575 Poppler Ave., Memphis, Tennessee 38117.
4 Agricultural Research and Development Statistical Information Systems, Unit 9601-190-1.
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