HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Dealy, J. Articles by Moeller, M. W. Search for Related Content PubMed PubMed Citation Articles by Dealy, J. Articles by Moeller, M. W.

Influence of Bambermycin on Salmonella Infectiion and Antibiotic Resistance in Swine¹

Litton Bionetics, Inc., Kensington, Md. 20795 and Hoechst-Roussel Pharmaceuticals Inc., Somerville, N. J. 08876

Abstract

Twenty weanling pigs infected with S. Typhimurium were fed control and 4.4 mg bambermycins per kilogram of diet in a 7-week study to determine the effect on quantity, prevalence, shedding and susceptibility of Salmonella. Special precautions were taken to eliminate cross contamination between infected and uninfected animals on both treatments.

Salmonella counts of the homogenized fecal samples were monitored to study the parameters before and after inoculation. Five colonies from each fecal specimen suspected of being Salmonella were isolated, serologically identified, and tested for susceptibility to 10 antibiotics.

The use of bambermycins supplemented feed reduced the duration and prevalence of Salmonella shedding in pigs. Bambermycins fed pigs showed an increased rate of shedding during the first 10 days and except for 2 days, the quantity of Salmonella shed was less. Furthermore, feeding bambermycins diets significantly reduced the number of Salmonella resistant to ampicillin, streptomycin, triple sulfa, and tetracycline.

Salmonella was not recovered from liver, spleen, or ileocaecal lymph nodes from any of the pigs at terminal necropsy. Three non-medicated pigs showed positive colon Salmonella cultures while only one of the bambermycins medicated animals showed a positive culture. This indicates that bambermycins did not increase the carrier state of Salmonella in pigs.

¹ The authors gratefully acknowledge the technical assistance of Eva Barrion. Thanks are due also to Charles Riggs and his staff for the statistical analyses.