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Glutathione Peroxidase Response to Selenium Intake in Lambs Fed a Torula Yeast-Based, Artificial Milk^{1, 2,}

University of Wisconsin, Madison 53706

Abstract

An 8-week experiment was conducted with 16 newborn lambs fed a Torula yeast-based, low selenium (Se), liquid diet (.01 ppm Se) supplemented on the basis of air-dried solids with 0, .05, .10 or .50 ppm Se supplied as Na₂SeO₃. The objective was to determine the effect of dietary Se intake on tissue glutathione peroxidase activity and Se concentration. Since glutathione peroxidase is a selenoenzyme, it was postulated that activity of this enzyme in tissues might be an index of Se adequacy. Dietary Se supplementation increased Se concentration and glutathione peroxidase activity in 10 different tissues analyzed, but some tissues responded more dramatically than others. In all tissues analyzed except pancreas and erythrocytes, glutathione peroxidase activity reached a plateau at approximately .11 ppm Se, but Se content of the tissues increased with each increment of dietary Se. Body weight gain and feed utilization were significantly (P<.05) lower in the basal group, however, no significant difference was observed in these parameters between the three supplemented groups. Tissue glutathione peroxidase was a better indicator of dietary Se adequacy than was tissue Se concentration. By this criterion, a total of .11 ppm Se on an air-dried solids basis (.12 ppm Se on a dry matter basis) satisfied the Se requirement of lambs fed the Torula yeast-based artificial milk diet but .06 ppm Se did not.

¹ Research supported by the College of Agricultural and Life Sciences, University of Wisconsin, Madison and by United States Public Health Service Program Grant No. AM-14881. Paper No. 669 from the Department of Meat and Animal Science.

² Departments of Biochemistry, Meat and Animal Science and Nutritional Sciences.