J. Anim Sci.
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J. Anim Sci. 1976. 42:901-911.
© 1976 American Society of Animal Science
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Effects of Various Doses of Prostin F2 Alpha® on Estrous Cycles, Rectal Temperature, Sweating, Heart Rate and Respiration Rate in Mares

P. A. Miller, J. W. Lauderdale and S. Geng1,2,

The Upjohn Company, Kalamazoo, Michigan 49001

Abstract

Mares of mixed breeding (379 to 594 kg) were injected intramuscularly once with Prostin F2 alpha® (PGF2{alpha}) in doses ranging between 0 and 10 mg between days 6 and 9 after ovulation. Prostaglandin F2{alpha} caused luteolysis as measured by reduction in intervals between injection and either return to estrus or ovulation and by reduction in interovulatory intervals for four of eight, seven of nine, eight of nine, four of eight, seven of nine and eight of eight mares treated with .25, 1, 2.5, 3, 5 or 10 mg PGF2{alpha}, respectively. Duration for both estrus and the estrous cycle subsequent to administration of Prostin F2 alpha was within the range accepted as normal indicating no carryover effects of treatment.

Sweating was not observed for mares treated with .25 mg PGF2{alpha} but was observed for mares treated with 1, 2.5, 3, 5 or 10 mg between 1/4 and 2 hr after injection. Most mares had ceased sweating within 1 hr after injection, but drying was not completed for up to 3 to 5 hr after injection. Rectal temperature was decreased significantly during the intervals 1/2 through 1, 1/2 through 4, 1/2 through 3, 1/2 through 5, or 1/4 through 5 hr after treatment of mares with 1, 2.5, 3, 5 or 10 mg PGF2{alpha}, respectively. Compared to appropriate controls, maximum temperature decrease of mares was on the order of .5 to .6 C for those treated with .25 or 1 mg, .9 to 1.2 C for those treated with 2.5, 3, or 5 mg, and 1.7 C for those treated with 10 mg PGF2{alpha}. Decreases in rectal temperature were associated with sweating and drying.

Footnotes

1 Agricultural Research and Development. A portion of these data were presented at the 1975 A.S.A.S. meeting, Colorado State University.

2 The authors express appreciation to E. J. Clark, M. J. Goodwin, and K. K. Krueger for technical assistance in executing this investigation.






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Copyright © 1976 by the American Society of Animal Science.