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Absorption as a Factor in Manganese Homeostasis¹

University of Georgia², Athens 30602

Abstract

⁵⁴Mn absorption and metabolism were studied in rats fed 4 to 1,000 ppm Mn in one experiment and 4 to 2,000 ppm in another for 12 or 14 days, prior to a single oral ⁵⁴Mn dose. One-half of the rats were killed at 4 hr and the others at 24 hr post-dosing. ⁵⁴Mn concentration declined with increasing dietary manganese in most tissues and in such body tissues as liver, kidneys, heart, testes and blood varied inversely with dietary level. Four hours after dosing, liver ⁵⁴Mn was 15 times higher in rats that had been fed 4 ppm than in those fed the 1,000 or 2,000 ppm diets (P<.05). The very large effect of dietary Mn on tissue ⁵⁴Mn in orally dosed animals indicates that variable absorption is an important factor in Mn homeostasis. From 4 to 24 hr after dosing, the relative differences in ⁵⁴Mn between those given the low and high Mn diets widened in many tissues, confirming earlier work that increased dietary Mn also accelerates ⁵⁴Mn turnover after absorption and tissue deposition. The results lead to the conclusion that variable absorption as well as variable excretion is important in Mn homeostasis.

¹ Supported in part by USPHS, NIH Grant Am-07367.

² Department of Animal and Dairy Science.