J. Anim Sci.
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J. Anim Sci. 1976. 42:599-607.
© 1976 American Society of Animal Science
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Efficacy of Menadione Dimethylpyrimidinol Bisulfite as a Source of Vitamin K in Swine Diets

R. W. Seerley1, O. W. Charles2, H. C. McCampbell1 and S. P. Bertsch1

College Station,3, University of Georgia, Athens 30602

Abstract

The efficacy and safety of the vitamin K derivative menadione dimethylpyrimidinol bisulfite (MPB) was tested in a series of three experiments for growing swine. In Experiment 1 feeding 1.1 mg/kg of diet of an anticoagulant stress agent (pivalyl) with .0, 1.1, 2.2, 4.4 or 8.8 mg of MPB/kg of diet decreased the prothrombin time from no clotting at the .0 level to plasma clotting after 152 sec (P<.05) at the 8.8 mg MPB level. Pigs fed pivalyl without MPB had the slowest rate of gain and lowest feed consumption (P>.05), and prothrombin time was prolonged indefinitely (P<.05). The addition of MPB in the diet overcame these effects.

Levels of 11.0 and 33.0 mg and 11.0, 35.2 and 110.0 mg of MPB per kilogram of diet in two experiments were used to observe the effect on pig performance and certain tissue and blood parameters compared to those fed control diets. In Experiment 2, three pigs were sacrificed at 3-week intervals in the 10-week test period and all pigs were sacrificed after 16 weeks in Experiment 3. No adverse effects from MPB were observed. All treatment groups had normal growth rates, feed conversion, prothrombin time, hematocrit, hemoglobin, total white cell counts and differential white cell counts. All pigs appeared healthy during the experiments and tissues of lungs, liver, spleen, kidney and intestinal tract appeared to be normal at necroscopy.

Footnotes

1 Department of Animal and Dairy Science.

2 Division of Poultry Science.

3 Supported by Grant-in-Aid by Heterochemical Corporation, 111 East Hawthorne Avenue, Valley Stream, New York, 11580.






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Copyright © 1976 by the American Society of Animal Science.