J. Anim Sci.
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J. Anim Sci. 1975. 41:1700-1705.
© 1975 American Society of Animal Science
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Prenatal Effects of Elymoclavine Administration and Temperature Stress1

Weldon L. Witters, Robert A. Wilms and Ronald D. Hood2

Ohio University, Athens 45701

Abstract

Elymoclavine, a toxic alkaloid produced by Claviceps purpurea growing on feed grains and forage grasses and produced by various bindweeds, was found to be embryocidal and teratogenic in mice when administered intraperitoneally at dose levels of 3, 30, or 60 mg/kg on the 10th day of pregnancy. Elevated environmental temperatures (35 C or 40 C) tended to exacerbate embryolethality. Maternal deaths were also noted at 30 C, 35 C and 40 C due to elymoclavine treatment. The fetal anomalies produced consisted largely of vertebral defects and fusion of the ribs.

Footnotes

1 Department of Zoology Paper.

2 Department of Biology, University of Alabama.






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