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Influence of Acute Tissue Injury on in vitro Incorporation of ⁶⁵Zn by Sheep Erythrocytes¹

UT-AEC Comparative Animal Research Laboratory, Oak Ridge, Tennessee 37830

Abstract

Labeled zinc incorporation by erythrocytes of diseased or injured animals may reveal zinc-status information when borderline zinc deficiencies exist. The ⁶⁵Zn uptake by red blood cells of skin-irradiated sheep was much greater than that of cells from control sheep, and factors affecting this uptake were studied. The increased ⁶⁵Zn uptake was not influenced by the change in packed cell volume, nor could the uptake be altered by extracorporeal irradiation of the red blood cells. The nominal rate of ⁶⁵Zn uptake during a 10-hr incubation period was .6% per hour for control cells and 1.4% per hour for cells from injured sheep. Hypoalbuminemia and hyperglobulinemia resulted from the irradiation injury, and this change in plasma composition could account for part, but not all, of the differences in uptake between cells from injured and control sheep. Significant differences between the cells from these two sources were still observed when the influence of the plasma was removed. These differences (1) could be due to an increased zinc permeability resulting from injury sustained by the cells as they circulated through injured tissue, or (2) may be associated with the role of zinc in would healing.

¹ Research carried out at the UT-AEC Comparative Animal Research Laboratory operated by the University of Tennessee for the U.S. Atomic Energy Commission, and supported by the U.S. Department of Agriculture, Agricultural Research Service, and University of Tennessee Agricultural Experiment Station.