J. Anim Sci.
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J. Anim Sci. 1975. 41:1660-1665.
© 1975 American Society of Animal Science
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Clinical Response of Dairy Cows with Ovarian Cysts to GnRH1, 2, 3, 4,

C. J. Bierschwal, H. A. Garverick, C. E. Martin, R. S. Youngquist, T. C. Cantley and M. D. Brown5

University of Missouri,6, Columbia 65201

Abstract

One-hundred-fourteen cows (30 Guernsey and 84 Holstein), diagnosed as having ovarian cysts via rectal palpation, were treated at randon with a single IM injection of either 50, 100 or 250 µg synthetic gonadotropin-releasing-hormone (GnRH) or a sham injection of the carrier vehicle for GnRH (0 µg). All animals were from one Guernsey and three Holstein herds maintained on a reproductive herd health program where routine examinations were performed at weekly or biweekly intervals. Clinical diagnosis of ovarian cysts was based upon the finding of a single or multiple formation of smooth, fluctuant, rounded structures of 2.5 cm in diameter or larger on one or both ovaries. Response to treatment was recorded as positive if the animal established a normal estrous cycle or conceived and negative if no change in character, size or location of the cystic structure could be determined in a 2-to 4-week period. Positive response to treatment was not significantly different among the groups that received GnRH (50, 100 and 250 µg), but each was different from the animals receiving 0 µg GnRH (P<.01). Positive response of cows in the 50, 100 and 250 µg groups was 18 of 28 (64%), 23 of 28 (82%) and 23 of 30 (77%), respectively, in contrast to 6 of 28 (21%) given 0 µg. For cows positively responding to treatment, the mean time in days from treatment to estrus, conception rates and services per conception for cows receiving 0, 50, 100 and 250 µg GnRH were 24.0, 4 of 6 (67%) and 1.5; 22.8, 13 of 18 (72%) and 1.6; 22.4, 20 of 23 (87%) and 1.6; and 22.2, 17 of 23 (74%) and 1.9, respectively.

Footnotes

1 Contribution from the Missouri Agricultural Experiment Station. Journal Series No. 7177. Approved by the Director.

2 These data were presented in part at the 66th Annual Meeting of the American Society of Animal Science, July 28 to 31, 1974, College Park, Maryland.

3 GnRH was generously supplied by Dr. M. D. Brown, Abbott Laboratories.

4 This research was conducted as part of regional research project NC-113, Endocrine Imbalances During Abnormal Reproduction in Cows.

5 Abbott Laboratories, Agricultural and Veterinary Products Division, North Chicago, Illinois 60064.

6 Department of Veterinary Medicine and Surgery and Department of Dairy Husbandry.






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Copyright © 1975 by the American Society of Animal Science.