J. Anim Sci.
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J. Anim Sci. 1975. 41:1407-1413.
© 1975 American Society of Animal Science
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Effects of Estradiol-17ß and Progesterone on Prostaglandins F in Sheep Uteri and Uterine Venous Plasma1

S. P. Ford2, C. W. Weems, R. E. Pitts3, J. E. Pexton4, R. L. Butcher and E. K. Inskeep

West Virginia University, Morgantown, 26506

Abstract

The effects of estrogen and progesterone on the content and concentration of prostaglandins F (PGF) in uterine tissue and venous plasma were investigated in ewes. Estradiol-17ß (.5 mg intramuscularly) on days 9 and 10 post-estrus increased the uterine venous plasma concentration (P<.01) and endometrial content and concentration (P<.05) of PGF in intact ewes sampled on day 11. The same dose of estradiol on days 4 and 5 had no effect on uterine venous plasma concentration or endometrial content of PGF in ewes sampled on days 6 or 6 and 9. After prior treatment with progesterone (10 mg per day on days 1 through 5) estradiol on days 4 and 5 did increase uterine venous PGF on days 6 and 9. Progesterone alone had no effect. Myometrial content and concentration of PGF were higher on day 11 than on day 6 regardless of whether ewes had received estradiol or corn oil.

In ovariectomized ewes, two injections of 12.5 µg of estradiol 12 hr apart increased PGF in uterine venous plasma 12 hr after the second injection in both control and progesterone-primed (5 days) ewes.

Footnotes

1 Published with the approval of the Director of the West Virginia Agr. Exp. Station as Scientific Paper No. 1371. Division of Animal and Veterinary Sciences and Department of Obstetrics and Gynecology. Supported by NIH Contract 69-2215. The authors gratefully acknowledge technical assistance by Phyllis Jenkins, Mary Ann Kline, Deborah Winger, R. L. Fogwell, W. J. Smutny, and Diana Kirkpatrick-Keller. Prostaglandin F2{alpha} for assay standard was provided by Dr. John E. Pike, The Upjohn Company. The antibody to PGF2{alpha} was a generous gift of Dr. Lawrence Levine, Brandeis University. Dr. W. V. Thayne assisted in statistical analyses of the data.

2 Present address: Department of Animal Science, Oregon State University, Corvallis.

3 Present address: School of Veterinary Medicine, Louisiana State University, New Orleans.

4 Present address: Department of Animal Science, Colorado State University, Fort Collins 80521.






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Copyright © 1975 by the American Society of Animal Science.