J. Anim Sci.
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J. Anim Sci. 1975. 41:1199-1205.
© 1975 American Society of Animal Science
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Duodenal Acidification: Stimulus for the Release of Intestinal Hormones in Sheep

Gerald W. Horn1 and Thomas L. Huber

University of Georgia2, Athens 30602

Abstract

Wethers with reentrant, common bile duct cannulas were used to characterize the effects of duodenal acidification or the intravenous infusion of secretin or cholecystokinin-pancreozymin (CCK-PZ) on pancreatic exocrine secretion and bile flow. The flow rates of the mixed, pancreatic-biliary secretions were all increased in response to the intraduodenal infusion of lactic acid or exogenous secretin or CCK-PZ. Duodenal acidification or exogenous secretin or CCK-PZ also effected increased bicarbonate outputs which were the greatest due to acidification of the duodenal intermediate for secretin, and the lowest in response to CCK-PZ. The quantities of protein secreted were characterized by nonsignificant (P>.05) initial increases followed by a rapid decrease or a fairly constant protein output in response to duodenal acidification or exogenous secretin, respectively. CCK-PZ effected a significant (P<.05) initial increase in pancreatic protein secretion, and the subsequent protein outputs during the infusion of CCK-PZ remained above the mean pre-infusion output. The data indicate that duodenal acidification is a more potent stimulus for the release of secretin than CCK-PZ in sheep, and that endogenous secretin may be a significant etiologic factor in the development of the ruminal atony associated with acute lactic acid acidosis of ruminants.

Footnotes

1 Present address: Department of Animal Sciences and Industry, Oklahoma State University, Stillwater 74074.

2 Department of Physiology and Pharmacology, College of Veterinary Medicine.






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Copyright © 1975 by the American Society of Animal Science.