J. Anim Sci.
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J. Anim Sci. 1975. 41:779-786.
© 1975 American Society of Animal Science
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A Review of the Role of Swine Skeletal Muscle in Malignant Hyperthermia

D. R. Campion1 and D. G. Topel2

Iowa State University, Ames 50010

Abstract

The syndrome of malignant hyperthermia (MHS) has been visualized from the point at which sarcoplasmic Ca2+ concentration becomes sufficient to stimulate phosphorylase kinase and, indirectly, myosin ATPase. Elevated levels of cellular Ca2+ may cause a functional uncoupling of oxidative phosphorylation as the mitochondria utilize high energy intermediates to sequester Ca2+. Consequently, ATP is consumed, and the cellular levels of ADP and inorganic phosphorus increases, further stimulating glycolysis as the MHS develops. As the mitochondria sequester Ca2+, O2 consumption is increased and this, in addition to the stimulating effect of temperature, may explain the observed increase in O2 consumption.

However, the triggering mechanisms that allow the various body functions, when exposed to halothane, to combine in an abnormal manner to produce what we recognize as malignant hyperthermia remain obscure.

Footnotes

1 U.S. Meat Animal Research Center, A.R.S., U.S.D.A., Clay Center, NE.

2 Journal Paper No. 8041 of the Iowa Agricultural and Home Economics Experiment Station, Ames. Project 2008.




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Copyright © 1975 by the American Society of Animal Science.