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Effect of Prostaglandin F₂ on the Estrous Cycle, Corpora Lutea and Progesterone Levels of Hysterectomized Cows^{1, 2,}

Montana State University, Bozeman 59715

Abstract

Eight cows, totally hysterectomized 9 to 13 days after estrus, were treated with either PGF₂ or saline to determine if PGF₂ is luteolytic in hysterectomized cows. PGF₂ was injected intramuscularly between 29 and 50 days after the last prehysterectomy estrus in either a single 30 mg dose or a 24 hr split dose of 8 and 4 mg, and saline was injected at volumes and times consistent with PGF₂ injections. Corpora lutea present at hysterectomy were marked with India ink for future identification at subsequent ovariectomy 5 to 7 days post-treatment.

PGF₂, but not saline, caused estrus 2 to 3 days post-treatment (P<.01) and reduced blood serum progesterone concentration from greater than 6 ng prior to treatment to less than 1.5 ng 1 to 5 days post-treatment (P<.01 days 1, 4 and 5 and P<.05 days 2 and 3 post-treatment).

Ovaries from PGF₂-treated cows, but not from saline-treated cows, showed evidence of recent ovulation and new corpus luteum development.

¹ Published with the approval of the Director of the Montana Agricultural Experiment Station, Journal Series No. 555.

² The authors wish to express appreciation to Dr. J. E, Catlin for technical assistance and for the use of the Veterinary Science Department facilities. They also wish to thank Mr. R. Kinkie for technical assistance. Prostaglandin F₂ was supplied by Dr. J. W. Lauderdale, Upjohn Company, Kalamazoo, Michigan. Anti- progesterone 6ß-BSA (869) was donated by Dr. G. D. Niswender, Colorado State University, Ft. Collins.

³ Animal and Range Sciences Department.

⁴ Present address: Inverness, MT 59530.

⁵ Chemistry Department. Present address: Department of Agricultural Chemistry, Washington State University, Pullman 99163.