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Effects of Dietary Restriction and Fasting on the Body Composition of Normal and Genetically Obese Mice

University of California, Davis 95616

Abstract

Two lines of mice differing in body weight and body composition, were compared under periods of restricted feeding and fasting regimens to assess changes in body composition. Restricted feeding of obese mice caused a reduction in body fat with little change in protein. The effect was strikingly more apparent in obese mice than in the normal (controls). A period of fasting caused marked protein catabolism with relatively much smaller changes in fat loss in obese mice. Restriction-fasting followed by restricted feeding of the obese line, then arrested protein catabolism but fat loss persisted. The data are consistent with the idea that adaptive lipolysis is induced by restrictive feeding and that fasting induces protein catabolism to facilitate gluconeogenesis from amino acids. On resumption of restricted feeding, protein catabolism is arrested but induced lipolysis persists.